Infrared Spectroscopic Identification of Enoxolone Active Pharmaceutical Ingredient in Compliance with Pharmacopoeial Standards

Abstract

Enoxolone (18β-glycyrrhetinic acid) is a naturally derived triterpenoid compound widely used as an active pharmaceutical ingredient (API) due to its antiinflammatory, gastroprotective, and antiviral properties. Ensuring the identity and quality of enoxolone in accordance with international pharmacopoeial standards is essential for pharmaceutical development and regulatory compliance. This study aimed to confirm the identity of industrially produced enoxolone substance using infrared (IR) spectroscopy in compliance with the requirements of the United States Pharmacopeia (USP), European Pharmacopoeia (Ph. Eur.), and national pharmacopoeial standards.