A high level of circulating immune complexes in patients with
glomerulonephritis is observed in connection with the activation of the immune
response to pathogenic antigens, and with a decrease in the mechanism of their
elimination. The latter may also be associated with a weakening of the function of
cells of the monocyte-macrophage system - cells that eliminate immune complexes.
The presence of a high CIC index in chronic GN is an alarming sign indicating an
ongoing immuno-inflammatory process in the body.
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